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VII. Distorted-Field Theory
(3/5 Pages) |
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3. Secondary Distortion
(a) The Meaning of Secondary Distortion
"Secondary Distortion" indicates amplified initial distortion, and which can be seen in the second stage of a pre-tumorigenic tissue. In two-stage carcinogenesis, a tissue treated with initiator distorts its metabolism, and causes initial distortion. After that, when a tissue already treated with initiator is also treated with promoter, it amplifies the initial distortion by changing the momentum. This amplified initial distortion indicates "Secondary Distortion." Indeed, it is important to distinguish between initial distortion and secondary distortion.
(b) Amplification of Secondary Distortion
Importantly, a tissue with initial distortion stepwise amplifies the initial distortion by changing the momentum. A tissue is created as a fractal structure, and the metabolism is controlled by fractalism. Thus, a tissue with initial distortion, by changing the momentum, amplifies the initial distortion step by step. Specifically, just when a tissue is oppressed by an external force, it starts absorbing the force by using the smallest fractal units. After the smallest fractal units reach their peaks, the tissue next starts absorbing the force by using the second-smallest units. Also after the secondary-smallest fractal units reach their peaks, the tissue also next starts absorbing the force by using the third-smallest units. Because of these fractal movements, a tissue with initial distortion amplifies the initial distortion step by step. In other words, we can also say that a distorted tissue amplifies the secondary distortion stepwise. The figure below illustrates this stepwise change. |
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(Because a tissue with tissue distortion absorbs an external force by using the fractal movement, it amplifies the tissue distortion stepwise.) |
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(c) Secondary Distortion Seen in The Esophagus
The esophagus, for instance, tends to easily cause secondary distortion when it is, for a long time, stimulated by strong liquor. Intoxicating liquor stimulates the esophagus very much, especially the mucous epithelium. By this mechanism, when the esophagus is stimulated by strong liquor for a long time, it not only causes initial distortion but also amplifies the initial distortion by decreasing the momentum. In other words, a person who has a habit of drinking strong liquor can be considered to easily cause secondary distortion in the esophagus.
Importantly, the esophagus frequently causes secondary distortion, the direction of which is from the lamina propria mucosae to the mucosal epithelium. In the esophagus, whereas the mucosal epithelium directly touches foods, other layers do not touch them. In addition, when the esophagus is, for a long time, stimulated by stimulants such as strong liquor, it decreases the momentum. By these two mechanisms, the esophagus frequently causes secondary distortion that is in direction from the lamina propria mucosae to the mucosal epithelium. This direction plays a major role in deciding where cancer occurs. |
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