Section: c1 | c2 | c3

Lastly, let us also analyze theoretically how the stomach causes leiomyosarcoma in the lamina muscularis mucosae. This process can be divided into three steps. At the first step, the stomach causes primary tissue distortion in between the lamina muscularis mucosae and the submucosa. This primary tissue distortion indicates initial distortion. At the next step, the stomach stepwise amplifies the initial distortion by decreasing the momentum, and causes secondary distortion. At the last step, in order to neutralize the secondary distortion, the stomach causes third distortion in the lamina muscularis mucosae. Just this third distortion has the ability to cause leiomyosarcoma in the lamina muscularis mucosae. In short, leiomyosarcoma occurs almost by the same mechanism as other two carcinogeneses already explained in the previous two sections.

(1) Outbreak of Tissue Distortion
(Outbreak of Initial Distortion)

In the stomach wall, when only the surface three layers, which are the mucosal epithelium, the lamina propria mucosae and the lamina muscularis mucosae, simultaneously reduce their metabolic activity, they cause primary tissue distortion that has the potential of causing leiomyosarcoma in the lamina muscularis mucosae. The stomach is created as a duct, the wall of which consists of several layers. Of these layers, when only the surface three layers strongly decrease their metabolic activity compared with other layers, they cause the imbalance in metabolic activity with other layers. This imbalance in metabolic activity works as primary tissue distortion: initial distortion. This initial distortion can theoretically be considered to have the potential of causing leiomyosarcoma that arises from the lamina muscularis mucosae in the stomach wall.

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