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logo of cancer III. Important Points for Theoretical Analysis of Carcinogenesis
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(10) Anatomy of the Stomach and Tissue Distortion Frequently seen in The Stomach

The stomach is created as a duct, the wall of which consists of several layers; this structure plays a major role in causing tissue distortion. The surface layer, which indicates the mucosal epithelium, always directly touches gastric juice, so that it easily loses the normal metabolic activity. Different from the mucosal epithelium, other layers, such as the lamina propria mucosae, the lamina muscularis mucosae and so on, do not directly touch stomach juice, so that they do not easily lose the normal metabolic activity. By this mechanism, the stomach wall will often cause the relative difference in metabolic activity between the mucosal epithelium and other layers. Just this relative difference in metabolic activity works as primary tissue distortion. I call this tissue distortion “Initial Distortion.”

Fig13. Structure in the Stomach and Tissue distortion

Notice that this type of tissue distortion can also be found in other hollow organs in a human body. Organs in a human body can roughly be classified into two types: hollow and solid organs. Of these two types of organs, hollow organs will often cause the same type of tissue distortion just like the stomach causes. Why? This is because a hollow organ is created as a duct or a sack, the wall of which consists of layers. Thus, hollow organs, which are the bronchus, the alimentary tract, the gallbladder, the bile duct, the urinary bladder, the uterus, the vagina and so on, cause the same tissue distortion as the stomach causes. That is, this type of tissue distortion can be considered one of the representative tissue distortions caused in a human body. I call this tissue distortion “Layer Distortion,” because its fundamental cause originates in layers forming the wall in an organ.

(A solid organ, different from a hollow organ, can be considered to usually cause tissue distortion due to the irregularity in fractalism or due to the relative difference in metabolic activity between the parenchymal and the interstitial cells. I call them “Fractal Distortion” and “P/I Distortion” respectively.)


Points:
1. The fundamental cause of tissue distortion originates in the structure of a tissue.
2. The stomach wall consists of several layers, which plays an important role in causing tissue distortion. As if the stomach causes tissue distortion due to the relative difference in metabolic activity between the layers, other hollow organs must cause the same type of tissue distortion as the stomach canses.


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