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logo of cancer III. Important Points for Theoretical Analysis of Carcinogenesis
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(3) Theoretical Analysis of Inflammation
“An organ causes inflammation in order to neutralize the imbalance in energy density between the organ itself and the background organs.” This indication can be deduced from theoretical analyses of swelling and atrophic change, and which are representative phenomena seen in a tissue with inflammation.

First of all, check theoretically how an organ causes swelling change. When an organ raises the momentum, it also raises the energy density. Simultaneously, the organ loses the balance in energy density with the background organs. (I call this imbalance in energy density “Energy Gap.”) A human body maintains the structure on the basis of the stability, which originates in the balance among the organs. Thus, the organ, which has lost the balance in energy density with the background organs, tries to neutralize the imbalance in energy density with the background organs; then, it reduces the high energy density by accumulating an excessive amount of watery fluid. As a result, the organ swells. This pathological change, of course, is frequently seen in a tissue with acute inflammation.

Next, also check how an organ causes atrophic change. By the opposite mechanism of swelling change, an organ becomes atrophied. When an organ reduces the momentum and decreases the energy density, it causes the imbalance in energy density with the background organs. Then, to neutralize the imbalance in energy density, the organ tries to raise the energy density by decreasing the volume. Through this process, an organ becomes atrophied. Needless to say, this pathological change is frequently seen in a tissue with chronic inflammation.

These two theoretical results bring us a new point of view toward two-stage carcinogenesis. Two-stage carcinogenesis needs two chemical substances: an initiator and a promoter. Of these two chemical substances, a promoter has the ability to cause acute inflammation in a tissue. In addition, theoretical analysis of swelling change has already pointed out that an organ with acute inflammation raises the momentum. Thus, a promoter can be considered a chemical substance having the ability to make a tissue raise the momentum. Of course, this means that a promoter also has the ability to make a cell increase the momentum.

Fig6: Theoretical Analysis
of Inflammation

Points:
1. When a human body loses the stability which originates in the balance among the organs, it causes disease to re-obtain the good balance. Theoretical analysis of inflammation clearly shows this fact: disease has the ability to allow a human body to regain good balance.
2. Of two chemical substances in two-stage carcinogenesis, a promoter plays a role in increasing momentum in a tissue or in a cell.

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