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logo of cancer IV-(a). Theoretical Analysis of Adenocarcinoma Arising from Atrophic Gastritis
Section: a1 | a2 | a3 | a4

(3) Direction of Amplified Distortion
(Direction of Secondary Distortion)

In the case of adenocarcinoma resulting from atrophic gastritis, the secondary distortion (= the amplified tissue distortion) is in the direction from the lamina propria mucosae to the mucosal epithelium. This stomach wall amplifies the tissue distortion by decreasing the momentum. In this process, the mucosal epithelium has decreased the metabolic activity, so that it strongly decreases the momentum. In contrast, the lamina propria mucosae, different from the mucosal epithelium, maintains good metabolic activity, so that it decreases the momentum in parallel to the momentum contained in the stomach wall. By these mechanisms, secondary distortion at adenocarcinoma enlarges in the direction from the lamina propria mucosae to the mucosal epithelium.

Importantly, the direction of secondary distortion plays a role in deciding where cancer occurs. Cancer, as explained before, occurs at the peak of strong tissue distortion. Additionally, in the case of adenocarcinoma, the secondary distortion is in the direction from the lamina propria mucosae to the mucosal epithelium, and its peak is in the mucosal epithelium. Thus, in the case of adenocarcinoma, when the stomach with tissue distortion strongly amplifies the tissue distortion by decreasing the momentum, it will next cause cancer in the mucosal epithelium nearby the lamina propria mucosae. As seen in this process, the stomach wall decides the outbreak point of cancer according to the direction of secondary distortion.

Fig19. Direction of The Amplified Tissue Distortion

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